Functional antibody screening
High-throughput droplet-based microfluidics
Our proprietary microfluidic platform combines single-cell analysis with droplet-based microfluidic sorting to identify functional antibodies against a broad spectrum of targets.
Our high-throughput workflow allows to analyze entire immune repertoires by multi-parametric functional micro assays to quickly identify and isolate antibodies that internalize or modulate receptor activity.
Droplets with an antibody-secreting cell are fused with droplets containing a reporter cell that expresses the target receptor.
Antibody binding to the reporter cell and functional response of the receptor cell can be detected in a single step based on a fluorescence high-throughput read-out.
Droplets are sorted and transferred to single cell sequencing.
We find the right antibody with the highest performance, speed, robustness, and efficiency.
ADCs need to bind the tumor cells very specifically with little off-target binding / effects.
ADCs then have to be internalized into the target cell very efficiently.
Within the target cells, ADCs need to be degraded in order to set the toxin free to yield the desired therapeutic effect.
Our bioengineering technology allows to position specific conjugation sites anywhere in the antibody. Our highly efficient click chemistry is then used to conjugate our payloads at these sites yielding efficacious, uniform and safe ADCs.Learn more